Asymmetric aza-Henry reaction of fluoromethylated imines catalyzed by cinchona-derived bifunctional thiourea.

DOI Number:

10.1016/j.tet.2018.12.055
Link to literature

Reaction Category:

Aza-Henry | Henry | Mannich | Nitro-Mannich

Educt:

fluoromethylated imines, nitromethane

Product:

(R)-4-methoxy-N-(1,1,1-trifluoro-3-nitropropan-2-yl)aniline

Catalyst:

N-[3,5-bis(trifluoromethyl)phenyl]-N′- [(8α,9S)-10,11-dihydro-6′-methoxy- cinchonan-9-yl]-Thiourea

Cas No:

852913-19-0

Associated Product from Buchler GmbH:

Dihydroquinine Base

Cas No:

522-66-7